Penetration of meropenem in lung, bronchial mucosa, and pleural tissues.
نویسندگان
چکیده
Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 patients undergoing lung surgery 1 to 5 h after administration of 1 g of meropenem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8.2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respiratory pathogens.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 43 3 شماره
صفحات -
تاریخ انتشار 1999